摘要硬化萎缩性苔藓(lichen sclerosus et atrophicus,LSA)常见于青春期前的女孩和绝经后的妇女.其发病机制比较复杂,在一定程度上与自身免疫性因素、遗传因素、炎症反应、感染及其他一些因素有关。至今该病发病机制仍不清楚,也无特效治疗方法。本文就国内外近年对该病的治疗进展作一概述。
1Navarro-Crummenauer B, Pickhardt CP, Urban R. Lichen sclerosus mistaken for sexual abuse-prevention of victimization [J]. Klin Padiatr, 2015,227(4) : 239-242.
2Sauder MB, Linzon-Smith J, Beecker J. Extragenital bullous lichen sclerosus [J]. J Am Acad Dermatol, 2014,71(5) :981-984.
3Anderson K, Ascanio NM, Kinney MA, et al. A retrospective analysis of pediatric patients with lichen sclerosus treated with a standard protocol of class I topical corticosteroid and topical calcineurin inhibitor [J]. J Dermatolog Treat, 2015:1-3.
5Fistarol SK, Itin PH. Diagnosis and Treatment of Lichen Sclero- sus : an update [ J ]. Am J Clin Dermatol, 2013,14 ( 1 ) : 27-47.
6Chi CC, Kirtsehig G, Baldo M, et al. Systematic review and meta-analysis of randomized controlled trials on topical interven- tions for genital lichen sclerosus [J]. J Am Acad Dermatol, 2012,67(2) :305-312.
7Bunker CB. Comments on the British Association of Dermatolo- gists guidelines for the management of lichen sclerosus [J]. Br J Dermatol, 2011,164(4) : 894-895.
8Laino L. Adjuvant clinical effects of polydeoxyribonucleotide in lichen sclerosus [J]. Eur J Dermatol, 2012,22(4) :575-576.
9Pope E, Doria AS , Theriauh M, et al. Topical imiquimod 5% cream for pediatricplaque morphea: a prospective, multiple- baseline, open-label pilot study [ J ]. Dermatology, 2011,223(4) : 363-369.
9Farrell AM,Marren PM,Wojnarowska F.Genital lichen sclerosus associated with morphoea or systemic sclerosis:clinical and HLA characteristics.Br J Dermatol,2000,143(3):598-603.
10Yang J,Chatterjee-Kishore M,Staugaitis SM,et al.Novel role of unphosphony level STAT3 in oncogenesis and transcription regulation Cancer Res,2005,65(8):939-947.