清喉消炎颗粒抗炎、镇痛作用研究

The roles of anti-inflammation and analgesia of Qinghouxiaoyan granules

目的:研究清喉消炎颗粒的抗炎、镇痛作用。方法:将动物分为空白组和清喉消炎颗粒高、中、低剂量组及阿司匹林组。通过二甲苯致小鼠耳肿胀、小鼠足跖肿胀法、小鼠腹腔毛细血管通透性、棉球致小鼠肉芽肿实验观察清喉消炎颗粒的抗炎作用;通过小鼠扭体法、小鼠热板法观察清喉消炎颗粒的镇痛作用。结果:清喉消炎颗粒对二甲苯、角叉菜胶、棉球致肉芽肿炎症均具有不同程度的对抗作用,可抑制小鼠腹腔毛细血管通透性;对热刺激和化学物质刺激致痛动物均有显著的镇痛作用。结论:清喉消炎颗粒具有抗炎、镇痛作用。

Objective To assess the anti-inflammatory and analgesic efects of Qinghouxiaoyan granules. Methods The rats were divided into blank group, Qinghouxiaoyan granules of high, medium, or low dose group, and aspirin group. Xylol-induced auricle swelling, carrageenan-induced paw swelling, Hac-induced blood capillary lealkage, and cotton pellet-induced graunloma were performed to assess the inflammatory effect; heat- plate test and Hac induced-twisting method were used to observe the analgesic efect. Results Qinghouxiaoyan granules played significant inhibitory action on xylene-induced inflammation, carrageenan-induced inflammation, and cotton-ball-induce granulation edema in different degrees; and decreased HAc-induced abdominal capillary permeability. The granules also showed significant analgesic effects on pain induced by heat and chemical stimulation in rats. Conclusion Qinghouxiaoyan granules has significant anti-inflammatory and analgesic effects.