孕酮、17β-雌二醇对在体培养人子宫内膜出血作用的初步研究

THE EFFECT OF PROGESTERONE AND 17β-ESTRADIOL ON INDUCTION OF HUMAN ENDOMETRIAL BLEEDING IN HAMSTER CHEEK POUCH

去卵巢地鼠皮下埋植孕酮和17β-雌二醇硅胶管,两周后在地鼠颊囊内移植分泌期人子宫内膜。手术后第11天用3种不同方式取出含类固醇激素管;1)10只动物仅取出17β-雌二醇管,保留孕酮管,移植内膜均无出血现象;2)31只动物取出孕酮管,保留17β-雌二醇管,有21只动物移植内膜出血,10只不出血;3)10只动物两种激素管同时取出,所有移植内膜均出血。内膜出血时间比较集中在取管后36—72小时内,占总出血动物的64％。文章讨论了子宫内膜出血原因。

A total of 51 ovariectomized hamsters previously treated with progesterone and 17 β-estradiol in silastic tube was used. After two weeks, the human endometrial tissues at the secretory phase were transplanted into the cheek pouch of hamster. The day of operation was defined as day O. On day 11, the steroids were withdrawn from hamster by three different ways as follows:1) Withdrawal of 17β-estradiol only, no bleeding occurred within 96 hrs in all of the grafts (10 grafts).2) Withdrawal of progesterone only, 31 animals in total, bleeding occurred in 21 grafts within 96 hrs; 10 grafts appeared unaffected.3) Withdrawal of both progesterone and 17β-estradiol, bleeding occurred within 96 hrs; approximately 64% falling between 36 and 72 hrs.The physiological mechanism of endometrial bleeding has been discussed.