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ADAR家族对5-羟色胺2C受体RNA编辑的研究进展

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摘要 RNA编辑是指转录后RNA分子的编辑过程,包含核苷酸的插入、删除和替换。RNA依赖腺嘌呤脱氨酶(RNA dependent adenosine deaminases,ADARs)是一类可以将5-羟色胺2C受体基因(HTR2C)的前体mRNA特定位点上的腺苷酸(adenosine,A)脱氨基转化为肌苷酸(inosine,I)的酶。A-to-I RNA编辑最终引起氨基酸的改变。本篇综述主要阐述ADAR家族对HTR2C的RNA编辑作用的相关研究进展,为防治HTR2C的RNA编辑异常引起的相关疾病提供理论依据。
作者 曾雯 于德钦 殷盛明
机构地区 大连医科大学七年制研究生 大连医科大学生理学教研室
出处 《生理科学进展》 CAS CSCD 北大核心 2015年第6期461-464,共4页 Progress in Physiological Sciences
基金 国家自然科学基金(31201724) 大学生科研创新活动基金资助课题
关键词 ADAR家族 RNA编辑 5-羟色胺2C受体
分类号 R338 [医药卫生—人体生理学]
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参考文献18

  • 1Giovanni Nigita, Salvatore Alaimo, Alfredo Ferro, et al.Knowledge in the investigation of A-to-I RNA editing sig-nals. Front Bioeng Biotechnol,2015 ,3 : 18.
  • 2Weidong Yang, Qingde Wang, Stephen J,Kanes, et al. Al-tered RNA editing of serotonin 5-HT2C receptor induced byinterferon : implications for depression associated with cyto-kine therapy. Mol Brain Res,2004,124 : 70 -78.
  • 3Chen CX, Gho Ds, Wang Q, et al. A third member of theRNA-specific adenosine deaminase gene family, ADAR3,contains both single-ang double-stranded RNA binding do-mains. RNA ,2000,6 : 755 - 767.
  • 4Wang IX,E So,J. L Devlin,et al. ADAR regulates RNA edi-ting, transcript stability, and gene expression. Cell Rep,2013,5 : 849 -860.
  • 5CHammiran Daniel, Gilad Silberberg, Mikaela Dehm, et al.Alu elements shape the primate transcriptome by cis-regula-tion of RNA editing. Genome Biol ,2014,15 : 28 -45.
  • 6Nishikara K. Functions and regulation of RNA editing by A-DAR deaminases. Annu Rev Biochem,2010,79 : 321 -349.
  • 7Wojciech Gamcarz, Aamira Tariq, Correlia Hand, et al. Ahigh throughput screen to identify enhancers of ADAR-medi-ated RNA-editing. RNA Biol,2013,10 : 192 -204.
  • 8Huiqi Hong,Jaynue Siqi Lin,Leilei Chen. Regulatory factorsgoverning adenosine-to-Inosine ( A-to-I) RNA editing. BiosciRep,2015 ,35 : 1 -8.
  • 9Chen W, Zhang Q, Su W, et al. Effects of 5-hydroxy-tryptamine 2C receptor agonist MK212 and 2A receptor an-tagonist MDL100907 on maternal behavior in postpartum fe-male rats. Pharmacol Biochem Be,2014,117 : 25 -33.
  • 10Mark R. Macbeth,Heidi L. Schubert, Andrew P. VanDe-mark,et al. Inositol Hexakisphosphate Is bound in the A-DAR2 Gore and Required for RNA Editing. Science,2005 ,309 : 1534 -1539.

二级参考文献13

  • 1Labasque M, Meffre J, Carrat G, et al. Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants. Mol Phar- macol,2010,78 : 818 - 826.
  • 2Herriek-Davis K, Grinde E, Lindsley T, et al. Oligomer size of the serotonin 5-hydroxytryptamine 2C (5-HT2C) re- ceptor revealed by fluoreseenee eorrelation spectroscopy with photon counting histogram analysis: evidence for homodim- ers without monomers or tetramers. J Biol Chem,2012,287 : 23604 - 23614.
  • 3Gobert A, Rivet JM, Lejeune F, et al. Serotonin 2C recep- tors tonically suppress the activity of mesocortical dopaminer- gic and adrenergic, but not serotonergic, pathways: a com- bined dialysis and electrophysiological analysis in the rat. Synapse,2000,36 : 205 - 221.
  • 4Gardier AM. Antidepressant activity: contribution of brain microdialysis in knock-out mice to the understanding of BD- NF/5-HTtransporter/5-HT autoreceptor interactions. Front Pharmacol,2013,4 : 98.
  • 5Hill RA, Murray SS, Halley PG, et al. Brain-derived neu- rotrophie factor expression is increased in the hippocampus of 5-HT ( 2C ) receptor knockout mice. Hippocampus, 2011, 21 : 434 -445.
  • 6Millan MJ. Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel- therapeutic strategies. Therapie ,2005,60 : 441 - 460.
  • 7Barbon A, Orlandi C, La Via L, et al. Antidepressant treat- ments change 5-HT2C receptor mRNA expression in rat pre- frontal/frontal cortex and hippocampus. Neuropsychobiolo- gy, 2011,63 : 160 - 168.
  • 8Moreau JL, Jenek F, Martin JR. Effects of repeated mildstress and two antidepressant treatments on the behavioral response to 5HT1C receptoractivation in rats. Psychophar- macology (Berl) , 1993,110 : 140 - 144.
  • 9Cremers TI, Rea K, Bosker F J, et al. Augmentation of SS- RI effects on serotonin by 5-HT2C antagonists : mechanistic studies. Neuropsychopharmacology, 2007, 32 : 1550 - 1557.
  • 10Vicente MA, Zangrossi H. Serotonin-2C receptors in the basolateral nucleus of the amygdala mediate the anxiogenic effect of acute imipramine and fluoxetine administration. Int J Neuropsychopharmacol,2011,14 : 1 - 12.

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生理科学进展
2015年 第6期

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