摘要
蛋白激酶A(PKA)是G蛋白偶联受体所介导细胞信号通路中重要的信号转导因子,广泛参与了伤害性信息的调控和痛觉过敏的形成。本文聚焦PKA的结构特点、分布、功能及其对疼痛的调控机制,以充实基于PKA信号通路的疼痛机制。
Protein kinase A was an important signal transduction factor participating in cell signaling pathways which was mediated by G protein coupled receptor,and involvement in the regulation of nociceptive information and the formation of hyperalgesia widely. In this paper,the structure characteristics,distribution,functions of PKA and its pain regulation were reviewed so as to enrich pain mechanism based on PKA signaling pathway.
出处
《延安大学学报（自然科学版）》
2015年第4期78-81,共4页
Journal of Yan'an University：Natural Science Edition
基金
国家自然科学基金面上项目(81171038
81470051)
陕西省科技厅项目(2010JM4041
2012K01-12)
陕西省教育厅项目(12JS121
15JF034)
延安大学陕西省高水平大学建设项目(2012SXTS06)
延安大学2015年研究生教育创新项目(21)
延安市科技创新团队和榆林市科技计划项目(2015CXY-21)
