肾细胞癌组织中VEGF和PDGF的表达

Expressions of VEGF and PDGF in the Renal Cell Carcinoma

目的探讨肾细胞癌组织中血管内皮生长因子(VEGF)和血小板衍生生长因子(PDGF)的表达及临床意义。方法采用免疫组化S-P法检测50例肾细胞癌和25例癌旁正常肾脏组织中VEGF和PDGF的表达,并分析两者与肾细胞癌临床病理参数的关系。结果肾细胞癌组织中VEGF和PDGF的阳性表达率分别为76.00%、78.00%,均高于癌旁正常膀胱组织的8.00%、4.00%(P均<0.05)。肾细胞癌组织中VEGF和PDGF的表达与其淋巴结转移、病理分化程度和临床分期有关(P均<0.05)。肾细胞癌组织中VEGF和PDGF的表达呈正相关关系(r=0.606,P<0.05)。结论肾细胞癌组织中VEGF和PDGF存在高表达,对其疾病进展具有促进作用,且两者的检测可用于肾细胞癌的预后评估和靶向治疗药物疗效的监测指标。

Objective To investigate the expressions and clinical significance of vascular endothelial growth factor（VEGF） and platelet-derived growth factor（PDGF） in the renal cell carcinoma. Methods Immunohistochemistry S-P method was used to detect the expressions of VEGF and PDGF in the 50 cases of renal cell carcinoma and the 25 cases of paraneoplastic normal renal tissue. The relationship between clinicopathological features and VEGF and PDGF were analyzed. Results The positive rate of VEGF and PDGF were 76.00% and 78.00% in the renal cell carcinoma, and were 8.00% and 4.00% in the paraneoplastic normal renal tissue （P 〈 0.05）. The expressions of VEGF and PDGF in the renal cell carcinoma were related with the lymph node metastasis, pathological cell differentiation degree and clinical stage（P 〈0. 05 ）. The expressions of VEGF was positively related with PDGF in the renal cell carcinoma（ r = 0. 606, P 〈 0.05 ）. Conclusion The high expressions of VEGF and PDGF are related to the progression of renal cell carcinoma, detection of them can be used to guide the targeted therapy and prognosis of renal cell carcinoma.