摘要
Albendazole is a benzimidazole derivative with broad spectrum of activity against nematodes and cestodes infections in animals. Bulk of the needed drugs in West African sub-region is imported and adulteration in drug trade is common. This study was aimed at examining the quality of nine brands of veterinary albendazole boluses commonly used in Nigeria. Bolus weight uniformity, assay, hardness, friability, disintegration time, and dissolution profiles of the brands （250 mg/bolus） were tested according to the official specifications. All the brands tested failed bolus weight uniformity test except brands C and H. The percent albendazole in brands A, B, C and F were within official specification whereas D, E, G, H and I failed. None of the brands passed hardness test. All the products passed friability test except brand E. All the test brands disintegrated within the specified time except B and H. Only brands B, C, E and I passed the dissolution test. Consequently, only brands B and C could be interchanged with the reference. There is need for routine quality control and post market surveillance of veterinary drugs in Nigeria.
