摘要
Ketoconazole has been widely used as an antifungal drug ketoconazole shampoo. The aim of this research was to study and to that is formulated as tablets, cream and over-the-counter standardize an UV （ultraviolet spectrophotometric） method, potentiometry and a HPLC （high performance liquid chromatographic） method for the determination ofketoconazole in commercially available tablets. These three methods were compared and discussed with respect to their sensitivity, selectivity and ready-applicability in routine analytical work. Absorption spectra and spectrophotometric determinations were carried out on the UV spectrophotometer. Investigated concentrations that ranged from 0.003 mg·dm^-3 to 0.02 mg·dm^-3. The absorbance was measured at 224 nm. In potentiometric titrations, glass and saturated （KCI） calomel electrodes were used to determine the end point of the titration. HPLC analyses of ketoconazole were carried in the presence ofeconazole as internal standard. It was concluded that the described methods are simple, fast and reliable for the identification of ketoconazole in pharmaceutical preparations. The preparation of the samples was easy, the excipients did not interfere with the active substance in the methods, so they can be used in routine quality control analysis.
