趋化因子CXCL10(IP-10)、MMP-1及TNF-α与腰椎间盘突出症的相关性研究

CORRELATION RESEARCH OF CXCLL0,MMP-1 AND TNF-ΑAND LUMBAR DISC HERNIATION

目的探索腰椎间盘突出症患者腰椎间盘组织炎症因子CXCLl0、MMP-1及TNF-α浓度的变化,以及其在腰椎间盘突出症发病中的作用。方法选取诊断为腰椎间盘突出症的患者为观察组,另取腰椎骨折手术患者受累椎间盘组织为对照组,采用ELISA法测定其CXCLl0、MMP-1及TNF-α水平,分析比较两组炎症因子浓度差异。结果两个观察组CXCLl0、MMP-1及TNF-α水平均高于对照组,差异有统计学意义(P<0.05),而且游离型组CXCLl0、MMP-1及TNF-α水平高于突出型组,差异有统计学意义(P<0.05)。结论 CXCLl0、MMP-1及TNF-α三种因子与腰椎间盘退变相关。

Objective To explore the changes and effect of CXCLl0,MMP-1and TNF-αin patients with intervertebral disc herniation.Methods The intervertebral disc herniation patients formed the observation group,and the patients with fracture of lumbar vertebra formed the contrast group.The levels of CXCLl0,MMP-1and TNF-αwere detected by ELISA method and the results were compared by statistical method.Results The levels of CXCLl0,MMP-1and TNF-αin the observation group were obviously higher than those in the contrast group（P〈0.05）.Conclusion The levels of CXCLl0,MMP-1and TNF-αare involved in the mechanism of intervertebral disc degeneration.