奥氮平联合运动疗法对糖尿病患者焦虑、抑郁状况的影响

EFFECT OF OLANZAPINE COMBINED WITH EXERCISE THERAPY ON ANXIETY AND DEPRESSION,PATIENTS WITH DIABETES MELLITUS

目的探讨奥氮平联合运动疗法对糖尿病患者血糖、焦虑及抑郁状况的影响。方法选取108例糖尿病焦虑及抑郁状况患者,随机分为观察组与对照组各54例,均给予二甲双胍降糖治疗(0.5g/次,3次/d)、饮食控制、健康教育等措施治疗。对照组在此基础上给予帕罗西汀(20mg/次,1次/d),观察组在此基础上实施奥氮平治疗(1.25mg/次,1次/d)联合运动疗法干预,治疗2个月后,对比分析两组患者治疗前后空腹血糖(FBG)、餐后2h血糖(2hFPG)、汉密尔顿焦虑抑郁量表(HAMD)焦虑及抑郁评分。结果两组治疗后FBG、2hFPG水平均低于治疗前(P<0.05),两组患者焦虑及抑郁评分均低于治疗前(P<0.05),观察组较对照组下降明显(P<0.05)。结论奥氮平联合运动疗法干预,能有效降低血糖、缩短血糖控制所需时间,明显缓解糖尿病患者的焦虑和抑郁症状,改善患者生活质量,副作用发生率低,安全有效。

Objective To investigate the effects of olanzapine combined with exercise therapy on blood glucose in diabetic patients,the anxiety and depression status.Methods 108 patients with diabetes mellitus anxiety and depression were randomly divided into observation group and control group（cases）.All 54 patients were treated with metformin（0.5g/times,3times/d）,diet control,health education and other measures.The control group based on given paroxetine（20mg,QD）were observed group on the basis of the implementation of olanzapine in the treatment of（1.25mg/time,1time/D）combined with exercise therapy intervention,2 months after treatment,comparative analysis two groups before and after treatment in patients with fasting blood glucose（FBG）,postprandial Hamilton Anxiety and depression and 2H plasma glucose（2hFPG）scale（HAMD）anxiety and depression scores.Results The levels of 2hFPG and FBG in the two groups were lower than those before treatment（P〈0.05）,the scores of anxiety and depression in the two groups were lower than those in the control group（P〈0.05）,and the observation group was significantly lower than that in control group（P〈0.05）.Conclusion Olanzapine combined with exercise therapy intervention,reduce blood sugar and shorten the time of blood glucose control,obviously alleviate the anxiety and depression symptoms in diabetic patients,improve the quality of life of the patients,the incidence of side effect was low,safe and effective.