不同粉体戊己丸中芍药苷溶出度研究

Study on Dissolution of Paeoniflorin in Wuji Pills of Different Powder Size

目的:建立戊己丸中芍药苷溶出度测定方法,并比较超微粉和普通粉戊己丸的溶出差异。方法:参照2010版《中国药典》(二部)溶出度测定第二法,以700mL水为溶剂,转速为100r/min,规定时间取样,以高效液相色谱法测定,比较两种不同粉体戊己丸的溶出度差异。结果:超微戊己丸的体外溶出速率快,溶出度高。结论:超微粉戊己丸的溶出速率快,有利于机体对药物的吸收,提高生物利用度。

Objective：To establish a method for the determination of dissolution rate of peoniflorin（PF）in Ultro-micro and Normal powder Wuji Pill and compare the dissolution difference.Methods：According to Appendix XCII of Chinese Pharmacopoeia 2010 edition Vol.II,the dissolution medium was 700 mL water and the rotating speed was 100r·min-1.The dissolution samples were taken at the required time,then analyzed with HPLC and compared the dissolution difference.Results：The Ultro-micro powder Wuji Pill had faster dissolution rate and higher dissolution efficiency.Conclusion：the study established a method for the determination of dissolution rate of peoniflorin and the dissolution rate of Ultro-micro powder Wuji Pill was faster,which was conducive to the absorption of drugs and improve bioavailability.