中药复方LC-MS技术研究进展

Research Advance on LC-MS in analyzing Chinese Traditional Compound Medicine

中药复方是中药的重要组成部分,是中医临床用药的主要应用形式,其研究是中药现代化进程的重要内容。液质联用(LC-MS)是将具有强分离能力的液相与强结构检测能力的质谱联用现代分析技术相结合,具有灵敏度高、检测限低、选择性强等优势,其在中药复方的应用也逐渐成为热点,主要应用于中药复方的成分分析、中药复方质量控制、中药复方药代动力学研究及中药复方代谢研究等四个方面。对LC-MS在中药复方研究的四个方面进行了综述,并讨论其存在的问题及发展前景。

Chinese Traditional Compound Medicine（CTCM）is an important part of traditional Chinese Medicine（TCM）,and the main applicant forms in TCM clinical medicine.The study on CTCM is a vital aspect in TCM modernization.LC-MS is a modern analytical technology that comined the LC with high separate ability and MS with strong structure detection ability.It has high sensitivity,low detection limit,strong selectivity and other advantages.Its application on CTCM is becoming a hotspot,including the component analysis,quality control,pharmacokinetic study,metabolism study of CTCM.LC-MS application on the four aspects above of CTCM was summarized,and the existing problems and development prosepects were also discussed.