摘要
目的:观察甲钴胺联合糖皮质激素、康复训练治疗前庭神经炎的临床疗效。方法:将61例前庭神经炎患者根据随机数字表法分为甲钴胺联合糖皮质激素、康复训练组,给予甲钴胺1mg静脉推注10d,后改为口服甲钴胺1.5mg/d,服用3个月,强的松1mg/kg,口服5d,联合康复训练;常规治疗组,强的松1mg/kg,口服5d,联合康复训练。随访期均为半年。用眩晕残障程度评定量表(DHI)评分和冷热试验半规管轻瘫(CP)进行临床疗效判定。结果:两组治疗后,1个月时DHI及CP均下降,但两组之间比较无显著性差异;在3个月时治疗组DHI较对照组下降明显,有显著性差异,CP较对照组有下降,但无统计学意义;6个月时,治疗组DHI较对照组无显著性差异,而CP较对照组有显著性差异。结论:甲钴胺联合糖皮质激素和前庭康复可以改善前庭神经炎眩晕残障程度,改善远期动态前庭失衡。
Objective： To observe the efficacy of methyleobalamin in combined with corticosteroids and vestibula reha- bilitation in the treatment of vestibular neuritis（VN）. Methods： 61 patients with VN were randomly divided into the methylcobalamin group （n--31） and the control group （n= 30）. The methylcobalamin group was treated with Intrave- nous Injection with methylcobalamin ling/d, and 10 days later, oral methylcobalamin 1.5mg/d, the course of treatment of methylcobalamin was 3 months. All patients were given corticosteroids（lmg/kg, for 5d） and vestibula rehabilita- tion. Follow-up period were 6 months. The efficacy was measured by Dizziness Handicap Inventory （DHI） and canal paralysis（CP）. Results：DHI score and CP of both groups were all decreased after 1 month, 3 months and 6 months. There were no significant reduction in DHI score and CP after 1 month, but a significant reduction in DHI score was found after 3 months and a significant reduction in CP after 6 months. Conclusion： It is possible to improve the dizziness handicap and long-term dynamic vestibular imbalances of VN by means of methylcobalamin in combined with cortico- steroids and vestibula rehabilitation.
出处
《医学理论与实践》
2015年第23期3174-3175,3185,共3页
The Journal of Medical Theory and Practice
