西酞普兰和舍曲林治疗癫痫性抑郁障碍的临床疗效及安全性研究

Study on the Clinical Efficacy and Safety of Citalopram and Sertraline in the Treatment of Epileptic Depression Disorder

目的探讨西酞普兰和舍曲林治疗癫痫性抑郁障碍的临床疗效与安全性。方法将82例癫痫性抑郁障碍患者分为两组,对照组应用舍曲林治疗,观察组应用西酞普兰治疗。结果两组患者临床疗效对比,差异无统计学意义(P>0.05);观察组不良反应要少于对照组(χ2=9.567,P=0.002)。结论西酞普兰与舍曲林治疗癫痫性抑郁障碍患者具有临床疗效,但是西酞普兰安全性要高于舍曲林。

Objective To investigate the clinical curative effect and security of citalopram and sertraline in treatment of the epileptic depression disorder. Methods 82 cases of epileptic depression disorder can be divided into two groups. Control group using sertraline for treatment, observation group was of citalopram for treatment. Results The clinical curative effect compared between the two groups, P 〉 0.05. Adverse reactions to observation group was obviously less than control group （ X 2 = 9.567, P=O.002 ） . Conclusion Epileptic depression disorder patients treated with citalopram and sertraline has significant clinical efficacy, but citalopram＇ security is significantly higher than that of sertraline.