IgG4表达调控因素及在疾病发生与治疗中的作用
摘要
人类免疫球蛋白G4（Immunoglobulin G4,Ig G4）是Ig Gs的亚型。Ig Gs在初次免疫应答中被较迟分泌,在二次免疫应答中被记忆B细胞大量分泌。Ig Gs依据重链序列、铰链区长度及链间二硫键连接位置和数目的差异,被分为Ig G1、Ig G2、Ig G3和Ig G4。健康个体Ig G4血浆浓度仅为0.08~1.4mg/ml,Ig G4/Ig G比值为0.8%-11.7%。
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2015年第12期1725-1728,共4页
Chinese Journal of Immunology
参考文献29
-
1Heads Jr, Adams R, D' Hooghe LE, et al. Relative stabilities of IgG1 and IgC,4 Fab domains: influence of the light-heavy interehain disulfide bond architecture [J]. Protein Sci, 2012,21 (9) :1315-1322.
-
2King D J, Adair JR, Angal S, et al. Expression, purification and characterization of a mouse-human chimeric antibody and chimeric Fab' fragment[J].Bioehem J,1992,281 (Pt 2) :317-323.
-
3Sehuurman J, Van Ree R, Perdok G J, et al. Normal human immu- noglobulin G4 is bispeeific:it has two different antigen-combining sites[ J]. Immunology, 1999,97 (4) :693-698.
-
4Stone JH, Zen Y, Deshpande V. IgG4-Related Disease [ J ]. N Engl J Meal,2012,366(6) :539-551.
-
5Meiler F, Klunker S, Zimmermann M, et al. Distinct regulation of IgE,IgG4 and lgA by T regulatory cells and toll-like receptors [J].Allergy ,2008,63 ( 11 ) : 1455-1463.
-
6Tsuboi H, Matsuo N, Iizuka M,et al. Analysis of IgG4 class switch- related molecules in IgC,4-related disease[ J]. Arthritis Res Ther, 2012,14(4) :R171.
-
7Kuroki A, Iyoda M, Shibata T, et al. Th2 eytokines increase and stimulate B cells to produce IgG4 in idiopathic membranous nephropathy[J]. Kidney Int ,2005,68( 1 ) :302-310.
-
8Tanaka A, Moriyama M, Nakashima H, et aL Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of mikuliez disease [ J ]. Arthritis Rheum, 2012,64 ( 1 ) : 254 -263.
-
9Punnonen J,Aversa C,Coeks BG,et aL Interleukin 13 induces in- terleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells[J].Proc Natl Acad Sci USA, 1993, 90 ( 8 ) :3730-3734.
-
10Satoguina JS, Weyand E, Larbi J, et al. T regulatory-1 cell induce IgG4 production by B cells:role of IL-10 [ J ]. J Immunol,2005, 174(8) :4718-4726.
-
1陈洋,唐静,张青,张大为,刘全胜.IL-21/4-IgG4融合基因的真核表达[J].四川大学学报（自然科学版）,2009,46(4):1213-1216.
-
2张大为,高闻达,张青,唐静,陈洋,刘全胜.人IL-32-IgG4(Fc)融合蛋白在CHO/DG44细胞中的表达[J].西北农林科技大学学报（自然科学版）,2009,37(6):7-13.
-
3许菲,赵鹏翔,吴亚楠,马雪梅.眼眶炎性假瘤发病机制的研究进展[J].医学综述,2013,19(21):3902-3904. 被引量：8
-
4赵荧,薄爱华,芦广萍,王金萍.PR、bcl-2在乳腺癌中表达及意义[J].河北北方学院学报（医学版）,2007,24(4):43-44.
-
5曹霞,谷欣权,王维忠.降钙素基因相关肽与心血管系统疾病[J].中国老年学杂志,2004,24(3):276-277. 被引量：12
-
6李庆生,吴圣楣,应大明,林梓.细胞因子对脐血B细胞免疫球蛋白类别转换的调节[J].微生物学免疫学进展,1998,26(2):11-13.
-
7Yongli Guo,Mingchun Gao,Junwei Wang.A novel gene encoding goose immunoglobulin λ light chain[J].Acta Biochimica et Biophysica Sinica,2012,44(9):805-806. 被引量：2
-
8祝申蓉,吴旭日,陈依军.microRNA定量检测方法的研究进展[J].中国药科大学学报,2015,46(1):40-49. 被引量：9
-
9路伟振,吴蓓丽,赵强.G蛋白偶联受体:七次跨膜结构的超级分子——2012年诺贝尔化学奖简介[J].自然杂志,2012,34(6):337-343. 被引量：9
-
10郑立恒,许松梅,何波,张青,熊华辉,刘全胜.EGFP-IgG4融合基因真核表达载体的构建及其表达[J].四川大学学报（自然科学版）,2007,44(3):711-714. 被引量：3
