分泌型卷曲相关蛋白5与动脉粥样硬化相关性研究进展

Research Progress of the Relationship between Sfrp5 and Atherosclerosis

分泌型卷曲相关蛋白5(Sfrp5)是Sfrp家族中的一员,是新近发现的一种脂肪因子,其作为Wnt信号通路的抑制剂,可竞争结合Wnt信号胞外配体Wnt5α蛋白,调节脂质代谢,改善胰岛素抵抗,维持炎症的平衡状态,也可参与胚胎发育及肿瘤的发生、发展。Sfrp5通过调节脂肪细胞分化、增强胰岛素敏感性、抵抗炎症反应等起到抗动脉粥样硬化(As)的作用。对Sfrp5与As相关作用机制进行研究,将为As疾病的早期诊断及治疗提供新的思路。

Secreted frizzled related protein 5（ Sfrp5）,a member of the Sfrps family,is a newly discovered adipokine. As an inhibitor of the Wnt signal pathway,it can regulate lipid metabolism,reduce insulin resistance,keep inflammation balance by competitively binding Wnt5α protein which is one of Wnt signaling pathway extracellular ligands. Sfrp5 can confrontate atherosclerosis by relulating adipocyte differentiation,strengthening insulin sensibility,and resisting inflammation. The exploration of the relationship between Sfrp5 and atherosclerosis can help to provide new ideas for prophylaxis and treatment of atherosclerosis.