子宫癌肉瘤的研究进展

The Research Developments in Uterine Carcinosarcomas

子宫癌肉瘤(UCS)是一种较少见的女性生殖道恶性肿瘤,其病因至今尚不明确,临床表现亦无特异性,很难在术前确诊,其诊断金标准为术后组织病理学检查。因其发病率低,大部分报道均为小样本回顾性研究,尚无统一的治疗模式,目前多推荐行全面分期手术及肿瘤细胞减灭术,术后行个体化辅助治疗,多推荐行化疗±放疗。虽然UCS在临床较少见,但其侵蚀性强,易于局部浸润和远处转移,即使是早期患者,预后亦极差,因此广大临床工作者需提高对UCS的认识以利于早期诊治。

Uterine carcinosarcomas（ UCS） is a rare female genital tract malignant tumor which lacks characteristic clinical manifestations and its etiology is not clear so far,thus can hardly be diagnosed before surgery. The gold diagnostic standard of UCS is postoperative histopathological examination. The incidence of UCS is low,and most reports are small sample retrospective studies,so it has no unified mode of treatment so far. Current guideline recommends comprehensive staged operation and cytoreductive surgery plus postoperative adjuvant therapy,which is highly individualized,with chemotherapy and / or radiotherapy as preferred option. The UCS is aggressive so local infiltration and distant metastasis may easily happen,even in the early stage. Because of its poor prognosis,awareness of UCS to improve the early diagnosis and treatment in the clinical is needed.