长春西汀葡萄糖注射液治疗急性脑梗死临床效果观察

Clinical Observation on Vinpocetine Glucose Injection for the Treatment of Acute Cerebral Infarction

目的评价长春西汀葡萄糖注射液治疗急性脑梗死的有效性和安全性。方法将60例急性脑梗死患者采用随机数字表法分为观察组和对照组,各30例,对照组采用一般对症支持治疗,观察组在一般对症支持治疗的基础上静脉滴注长春西汀葡萄糖注射液20 mg,静脉滴注,共10 d。治疗后10 d采用美国国立卫生院脑卒中量表对患者进行疗效评价。结果治疗10 d后,两组患者实验室指标均未见明显异常。观察组脑卒中量表评分低于对照组[(12.68±1.19)分比(15.11±1.38)分,P<0.01]。观察组总有效率显著高于对照组[86.7%(26/30)比63.3%(19/30),P<0.05]。结论长春西汀葡萄糖注射液治疗急性脑梗死安全、有效。

Objective To evaluate the efficacy and safety of vinpocetine glucose injection in the treatment of acute cerebral infarction. Methods Total of 60 patients with acute cerebral infarction were divided into observation group and control group by random number table method,with 30 cases in each. The control group was given general symptomatic and supportive treatment,while the observation group was given general symptomatic support treatment plus vinpocetine glucose injection 20 mg,intravenous drip,10 d in total. The National Institutes of Health Stroke Scale was adopted for efficacy evaluation 10 d after treatment. Results There were no obvious abnormalities in laboratory indexes of the two groups 10 days after treatment. The stroke scale in the observation group was lower than that in the control group [（ 12. 68 ± 1. 19） scores vs（ 15. 11 ± 1. 38） scores,P〈0. 01]. The total effective rate in the observation group was significantly higher than that in the control group [86. 7%（ 26 /30） vs 63. 3%（ 19 /30）,P〈0. 05]. Conclusion Vinpocetine glucose injection is effective and safe for the treatment of acute cerebral infarction.