小儿肺炎支原体肺炎尿微量蛋白检测的临床意义

Clinical significance in the detection of uromicroprotein in children with mycoplasma pneumonia

目的通过测定尿微量蛋白含量,探讨肺炎支原体肺炎患儿尿β2-微球蛋白(β2-MG)变化及其临床价值。方法检测50例健康儿童和98例肺炎支原体肺炎患儿尿常规、尿微量蛋白、血尿素(UREA)、血肌酐(CR)等指标进行对比分析。结果肺炎支原体肺炎患儿尿β2-MG含量[(0.47±0.32)mg/L]显著高于对照组[(0.13±0.12)mg/L](P<0.01);肺炎支原体肺炎患儿尿微量蛋白的异常检出34例(34.7%),尿常规异常检出9例(9.2%),差异有统计学意义(P<0.01)。结论肺炎支原体肺炎对小儿肾功能有不同程度的损害,尿β2-MG测定对肺炎支原体肺炎患儿肾功能损害的的早期诊断具有临床参考价值。

Objective To explore changes in β2-microglobulin（ β2-MG） levels through the detection of uromicroprotein in children with mycoplasma pneumonia and its clinical value. Methods Levels of urine routine,uromicroprotein,urian,creatinine（ CR） and other indicators were detected in 50 healthy children and 98 child patients with mycoplasma pneumonia,and comparisons were made between them. Results The level of β2-MG[（ 0. 47 ± 0. 32） mg / L]in the children with mycoplasma pneumonia was significantly higher than that of the control group [（ 0. 13 ± 0. 12） mg / L ]（ P〈0. 01）. Thirty-four cases of urinary micoalbuminuria（ 34. 7%） were detected in the children with mycoplasma pneumonia,and 9 cases urinary micoalbuminuria（ 9. 2%） were detected through urine routine. Statistical significance could be found,when comparisons were made between the two（ P〈0. 01）. Conclusion Mycoplasma pneumonia could damage the renal function of the child patients to various extents. The detection of β2-microglobulin level was of clinical significance to the early diagnosis of renal dysfunction of children with mycoplasma pneumonia.