危险因素对胃黏膜癌前病变中血管内皮生长因子表达的影响

The influence of risk factors on vascular endothelial grouth factor expression in precancerous lesion of gastric cancer

目的探讨各种危险因素与胃癌癌前病变(precancerous lesions of gastric cancer,PLGC)中血管内皮生长因子(vascular endothelial grouth factor,VEGF)表达的关系。方法收集胃镜和病理结果提示PLGC的患者,免疫组化检测VEGF的表达。对患者的吸烟、饮酒、饮食情况、个人史、家族史、H.pylori感染等因素与VEGF表达的关系进行分析。结果单因素分析表明,有5项危险因素(吸烟、胆汁反流、肿瘤家族史、慢性萎缩性胃炎、个人史和H.pylori感染)在VEGF表达阴性组、阳性组差异有统计学意义(P<0.05),多因素Logistic回归分析显示,吸烟、胆汁反流、H.pylori感染对PLGC中VEGF表达有影响,OR值分别为3.386、3.027、3.884。结论吸烟、胆汁反流、H.pylori感染是PLGC中VEGF表达的影响因素。

Objective To investigate the relationship between the various risk factors and vascular endothelial grouth factor （VEGF） expression in the precancerous lesions of gastric cancer. Methods The patients with PLGC confirmed by gastroscope and pathology results were collected. The expression of VEGF was detected by immunohistochemical. The relationship of the expression of VEGF with smoking, drinking, diet condition of patients, personal history, family histo- ry of Helicobacter pylori （H. pylori） infection was analyzed. Results Single factor analysis showed that five risk factors （smoking, bile reflux, tumor family history, personal history of chronic atrophic gastritis and H. pylori infection） be- tween VEGF positive group and VEGF negative group had statistically significant （P 〈 0.05） , the multiple factors Lo- gistic regression analysis showed that smoking, bile reflux, H. pylori infection had affection on VEGF expression in PL- GC, OR values were 3. 386, 3. 027, 3. 884. Conclusion Smoking, bile reflux and H. pylori infection were influencing factors on VEGF expression in PLGC.