843例患者幽门螺杆菌感染及耐药情况分析

Analysis to Infection and Antibiotic Resistance of Helicobacter Pylori in 843 Cases

目的:分析我院上消化道症状患者幽门螺杆菌(Hp)感染及耐药性,为Hp根治提供临床依据。方法:回顾性调查2014年来我院行胃镜检查的843例患者的Hp感染率和耐药率。结果:843例患者中Hp感染者330例,阳性率39.15%,对阿莫西林、四环素、呋喃唑酮3种药物全部敏感,左氧氟沙星耐药率25.76%,克拉霉素耐药率20.30%,甲硝唑耐药率为96.36%。结论:依据药敏试验进行抗Hp治疗,是治疗的最佳选择,本地区临床经验治疗最佳方案为铋剂四联治疗,慎用标准三联疗法和左氧氟沙星三联疗法。

Objective： To analyze the infection and antibiotic resistance of Helicobacter pylori（ Hp） in Huzhou area. Methods： The infection rate and resistance rate of 843 cases with upper gastrointestinal disease patients were analyzed retrospectively form Mon. 2013 to Dec. 2014. Results： A total of 843 speimens of patients,gastric mucosa tissue were examined,and 330 strains of Hp were detected（ 39. 15%）. The drug susceptibility test were performed,the results indicated that Hp were all sensitive to amoxicillin,tetracycline and furazolidone. The antibiotic resistance rates to levofloxacin,clindamycin and metronidazole were 25. 76% 、20. 30% and 96. 36% respectively. Conclusion： Eradication of Hp on durg sensitivety test was the optimal treatment selection,so the best plan-bismuth agent quadruple therpy should be used,not use or cautiously use the standard triple therapy and levoflxacin triple therapy.