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血管紧张素转换酶2-血管紧张素-(1-7)-Mas受体轴与血管内皮细胞凋亡 被引量：2

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摘要 肾素-血管紧张素系统经典轴血管紧张素转换酶(angiotensin converting enzyme,ACE)-血管紧张素(Ang)Ⅱ-血管紧张素Ⅱ1型受体(angiotensin 1 receptor,AT1R)在血管疾病致病机制中发挥重要作用。ACE2-Ang-(1-7)-Mas受体轴与ACE-AngⅡ-AT1R轴是一对负向调节轴,其通过抑制血管内皮细胞凋亡和平滑肌细胞凋亡,改善血管内皮功能、抑制血管重构,可能成为治疗血管性疾病的前景治疗靶点。
作者 肖红丽 王艳 王国兴 李春盛
机构地区 首都医科大学附属北京友谊医院急诊科 首都医科大学附属北京朝阳医院急诊科
出处 《中国医刊》 CAS 2015年第12期20-24,共5页 Chinese Journal of Medicine
基金 国家自然科学基金(81101400)
关键词 血管内皮细胞 凋亡 血管紧张素转换酶2 血管紧张素-(1-7) MAS受体
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献24

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二级参考文献61

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共引文献26

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二级引证文献2

中国医刊
2015年 第12期

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