中西医结合治疗Ⅲc期复发性卵巢癌的临床研究

Clinical Study on Integrated Traditional and Western Medicine in the Treatment for Recurrent Ovarian Cancer Stage Ⅲc

[目的]探讨中西医结合治疗卵巢癌的优势。[方法]回顾性分析Ⅲc期复发性卵巢癌患者65例,比较中西医结合组和西医组治疗的疗效。[结果]Cox多因素分析年龄、病理类型、组织分化、治疗方式、家族肿瘤病史对总生存的影响,结果显示,治疗方式是影响总生存的因素(P<0.05)。中西医结合治疗后中位生存时间为61个月,西医组52个月,中西医结合组的中位生存时间、总生存时间与西医组比较差异均无统计学意义(P>0.05)。中西医结合组1年生存率为100.00%,2年生存率为93.37%,3年生存率为80.83%,4年生存率为56.95%,5年生存率为12.50%;西医组分别为98.46%、88.52%、68.12%、41.72%、4.28%。中西医结合组3年、4年、5年生存率明显高于西医组(P<0.05)。[结论]中西医结合治疗Ⅲc期复发性卵巢癌长期疗效优于单纯西医治疗。

[Purpose]To investigate the advantage of integrated traditional and western medicine in the treatment for ovarian cancer. [Methods] Clinical data of 65 cases with recurrent ovarian cancer stage Ⅲc were analyzed retrospectively. [Results]Age,pathologic type,histologic differention,treatment modality,family history of cancer were analyzed by Cox multivariate analysis method,and the results showed that treatment modality was the independent factor for prognosis（P〈0.05）.The median survival was 61 months for integrated traditional and western medicine group,and52 months for western medicine group. Whereas,there were no significant difference in median survival and overall survival between the two groups（P〉0.05）. The 1-,2-,3-,4-and 5-year survival rates in integrated traditional and western medicine group were 100.00%,93.37%,80.83%,56.95% and 12.50%;and those were 98.46%,88.52%,68.12%,41.72% and 4.28% respectively in western medicine group. The 3-,4-and 5-year survival rates were significant higher in integrated traditional and western medicine group than those in western medicine group（P〈0.05）.[Conclusion] Integrated traditional and western medicine have superior long-term response for recurrent ovarian cancer stage Ⅲc than western medicine alone.