摘要
[目的]探讨甲状腺低分化癌的临床病理特点,分析其与甲状腺乳头状癌、未分化癌的差异。[方法]收集甲状腺低分化癌25例、乳头状癌40例、未分化癌20例,观察其组织学形态及临床特点。[结果]组织学上甲状腺低分化癌呈实性、岛状或梁状排列,并以单独或混合方式存在,其中9例合并有滤泡癌或乳头状癌;最大径平均值为5.43cm,明显大于乳头状癌的2.08cm,与未分化癌的5.12cm类似;易局部浸润及血管侵犯,复发和远处转移率高。[结论]甲状腺低分化癌的恶性程度介于乳头状癌与未分化癌之间,尽管10年生存率较高,但病程持续时间长,其长期无瘤生存率并不理想。
[Purpose] To investigate the clinicopathological features of poorly differentiated thyroid carcinoma（PDC） and to analyze the difference from papillary thyroid carcinoma（PTC） and undifferentiated carcinoma of thyroid（UDC）. [Methods] Clinical and pathological data of 25 cases with PDC,40 cases with PTC,and 20 cases with UDC were analyzed. [Results] Histologicallly,PDC was characterized by pure or mixed solid/trabecular/insular growth pattern. Coexistent follicular thyroid carcinoma or PTC was observed in 9 cases of PDC. The maximum diameter of PDC（5.43cm） was significantly larger than that of PTC（2.08cm） but similar to that of UDC（5.12cm）.PDC tended to present invasive growth and vascular invasion and showed high recurrence and distant-metastasis rate. [Conclusion] PDC shows malignant biological behavior between PTC and UDC,and shows a relatively high 10-year survival rate,moderate disease-free survival.
出处
《肿瘤学杂志》
CAS
2015年第11期895-899,共5页
Journal of Chinese Oncology
关键词
甲状腺肿瘤
低分化癌
临床病理学
诊断
预后
thyroid neoplasms
poorly differentiated carcinoma
clinicopathology
diagnosis
prognosis
