食管癌的全基因组关联研究进展

Research Progress in Genome-wide Association Studies of Esophagus Cancer

基因—环境和基因—基因交互作用在食管癌发生发展中起着重要作用。全基因组关联研究(genome-wide association study,GWAS)已发现一些与食管癌相关的易感位点和区域,为食管癌的预防和诊治提供了新的思路和方向。文章对近几年来关于食管癌的GWAS进展进行综述,分析GWAS在食管癌研究中的优点和应用前景。

Gene-gene and gene-environment interaction play important roles in the pathogenesis of esophageal cancer. Gnome-wide association study（GWAS） have discovered a series of suscep- tibility genes and loci which provide us new strategies for the prevention, diagnosis and treat- ment of esophageal cancer. In this article,the progress in GWAS of esophageal cancer is re- viewed, and the advantages as well as the perspective of its application are discussed.