摘要
目前应用肿瘤干细胞表面标志鉴定、分选干细胞的方法,已经在多种肿瘤中发现了肿瘤干细胞。而不少肿瘤干细胞表面标志是未知的,因此可以通过初次分离得到干细胞样细胞再鉴定出肿瘤干细胞。侧群细胞是具有干细胞样特性的细胞,它们具有起始肿瘤发生、表达干细胞样基因及耐受化疗药物的特性。文章就侧群细胞的分选方法、特征、在肿瘤干细胞研究中的应用及存在的问题进行综述。
Cancer stem cells（CSCs） have been found to exist in multiple types of tumor. They are often identified and isolated by the presence of specific surface markers. However,there are still many kinds of CSCs without any markers identified. Side population（SP） cells are one kind of cells sharing CSC characteristic,which play an important role in cancer initiation. They express stem-like genes and are resistant to chemotherapeutic drugs. This review is intended to appraise the sorting method,characteristics,the application in the cancer stem cells＇ research and the existing problems of SP cells.
出处
《肿瘤学杂志》
CAS
2015年第11期928-933,共6页
Journal of Chinese Oncology
关键词
侧群细胞
肿瘤干细胞
ABC转运蛋白
Cancer stem cells（CSCs） have been found to exist in multiple types of tumor. They are often identified and isolated by the presence of specific surface markers. However,there are still many kinds of CSCs without any markers identified. Side population（SP） cells are one kind of cells sharing CSC characteristic,which play an important role in cancer initiation. They express stem-like genes and are resistant to chemotherapeutic drugs. This review is intended to appraise the sorting method,characteristics,the application in the cancer stem cells＇ research and the existing problems of SP cells. side population cell
cancer stem cell
ABC transporter protein
