静电纺玉米醇溶蛋白纳米纤维及其药物缓释行为

Electronspun Zein fiber and its slow-release drug delivery behavior

利用静电纺丝法制备了玉米醇溶蛋白(Zein)、Zein/乙二醛交联纳米纤维,分别制得了负载不同质量药物的载药纳米纤维膜,并对纤维膜形态与结构进行了表征,研究了药物缓释行为。利用扫描电镜(SEM)对交联前后与负载药物后纳米纤维的形貌和直径分布进行了分析;强力测试结果表明,乙二醛交联后的Zein纳米纤维强度提高了近10倍;傅里叶变换红外光谱(FTIR)研究了Zein、乙二醛与药物之间的分子间作用力;紫外可见光(UV-Vis)光谱分析表明,乙二醛交联Zein载药纤维累积释放率比未交联的高且有一定的缓释效果。

Zein fiber and Zein/glyoxal crosslinked nanofiber are prepared by electrospinning technique, which are then used to fabricate the drug-loaded nanofibers. The morphology and structure of the nanofibers are characterized by SEM. The interactions of Zein, glyoxal and drug molecule are studied by FTIR. The drug delivery behavior is also investigated by UV-Vis. The results show that, in comparison with Zein nanofiber, Zein/glyoxal erosslinked nanofiber has improved the textile strength for about ten folds and the drug-loaded crosslinked nanofiber also has higher cumulative release rate of drug.