摘要
皮肤瘙痒是肝胆源性疾病的常见症状之一。目前肝胆源性疾病引起瘙痒的发病机制仍不明确,初步提出潜在的致痒因子包括胆盐、组胺、孕酮代谢产物、溶血磷脂酸、内源性阿片样物质等。现有治疗方法包括熊去氧胆酸、阴离子交换树脂、阿片受体拮抗剂、5-羟色胺3受体拮抗剂、抗组胺药、肝药酶诱导剂、MARS等仅可使部分患者症状得到缓解。为此,关于肝胆源性疾病引起的皮肤瘙痒发病机制和治疗方案仍需进一步深入探讨研究。
Pruritus, or itch is a common complaint in patients with hepatobiliary diseases. The underlying pathogenesis remains obscure with several mediators possibly playing significant role, including bile salts, histamine, progesterone metabolites, lysophosphatidic acid and opioids. The present management of pruritus include ursodeosychol-ic,anion exchange resin, opioid receptor antagonist, 5-HT3 receptor antagonist, antihistamine, liver enzyme inducer and MARS. However,the current management c.an only alleviate the symptoms in some of the patients. Therefore the pathogenesis and management of pruritus in patients with hepatobiliary diseases should be studied intensively.
出处
《中国医学文摘（皮肤科学）》
2015年第6期593-597,共5页
China Medical Abstracts(Dermatology)
关键词
瘙痒
肝胆源性疾病
胆汁瘀积
Pruritus
Hepatobiliary disease
Cholestasis
