脑白质疏松症的危险因素分析

The Analysis of the Risk Factor for Leukoaraiosis

目的探讨脑白质疏松症(leukoaraiosis,LA)的危险因素。方法回顾性调查250例曾行头颅磁共振成像(magnetic resonance imaging,MRI)检查的患者,根据检查结果将其分为脑白质疏松症组(LA组)150例,无脑白质疏松症组(对照组)100例。所有研究对象均完善相关的脑白质疏松症危险因素调查,进行单因素分析及二元Logistic回归分析。结果 (1)单因素分析显示,高血压、年龄、总胆固醇(total cholesterol,TC)、低密度脂蛋白(low density lipoprotein,LDL)、同型半胱氨酸(homocysteine,HCY)与脑白质疏松症有关(P<0.05)。(2)二元Logistic回归分析显示,年龄、高血压、同型半胱氨酸(HCY)为脑白质疏松的危险因素(P<0.05)。结论年龄、高血压、HCY为LA的危险因素。

Objective To explore the risk factors for leukoaraiosis （LA）. Methods Two hundred and fifty inpatients underwent the cranial magnetic resonance imaging （MRI） were investigated retrospectively. Totally, we identified 150 eligible cases with LA and 100 eligible cases without LA which were diagnosed via MRI. The latter served as control group. These enrolled cases all had the results of the questionnaires included questions about the risk factors for LA. All the data were collected, the univariate analysis and the binary logistic regression analysis were performed using software to explore the risk factors for LA. Results （1） The univariate analysis showed that hypertension, age, total cholesterol （TC）, low densityl ipoprotein （LDL） and homocysteine （HCY） were associated with LA （P〈0.05）. （2） The binary logistic regression analysis showed that age, hyperte nsion, and HCY were risk factors for LA （P〈0.05）. Conclusion Age, hypertension, HCY are risk factors for LA.