乌海市健康无偿献血者丙氨酸氨基转移酶参考值调查

A survey of alanine aminotransferase reference value of healthy and voluntary blood donors in Wuhai

目的对乌海市健康无偿献血者进行了丙氨酸氨基转移酶参考值调查。方法选取2013年6月～2014年1月的乌海市18～55周岁的经健康咨询体检合格、酶免四项检测合格的健康无偿献血者2455人，分为男女两组，分别对其ALT水平进行统计学分析研究。结果乌海地区健康无偿献血者ALT活性参考区间男性上限为57．62U／L，女性上限47．92U／L，与卫生部发布的卫生行业标准有一定差距。结论ALT生理波动性较大，身体肥胖、饮酒、睡眠不足、疲劳、剧烈运动及使用某些药物，均可能使ALT水平升高。因此，ALT标准参考值的确定还需要进一步去论证、细化，根据不同地区、不同人群去设定。

Objective To conduct a survey of alanine aminotransferase reference value of healthy and voluntary blood donors in Wuhai. Methods 2 455 healthy and voluntary blood donors 18～55 yeas old in June 2013 to January 2014 with health consultation, physical fitness and ELISA tested negative for anti-HCV, HBsAg, HIV and TP were choose. They were divided into male and female groups, and the level of alanine aminotransferase （ALT） were analyzed through statistics respectively. Results We found that ALT upper limit of male is 57.62U/L, ALT upper limit of female is 47.92U/L in Wuhai healthy and voluntary blood donors, there is a distance between the values we got and standard values issued by Ministry of Health. Conclusions physiological measurement value of ALT is generally volatile, either obesity, drinking, sleep insufficiency, fatigue, strenuous exercise, or the use of certain drugs might led to the increase of ALT level. Therefore, the standard reference value of ALT is subject to some debate and subdivided according to different region and population.