2014年供血浆人群及血液制品戊型肝炎病毒感染情况分析

Analysis of HEV infection in plasma donors and blood products in 2014

目的分析2014年供血浆人群及血液制品的戊型肝炎病毒(hepatitis E virus,HEV)HEV感染情况。方法采用ELISA法对不同省份(四川省、山东省、山西省)供血浆人群血浆样品进行HEV Ag、HEV Ig M和HEV Ig G的检测,并对HEV Ag阳性供血浆者作追踪分析;对合并血浆及血液制品成品进行HEV Ag检测。结果 36 340份供血浆者样品中有HEV Ag阳性26份(0.07%);3 780份血浆样品中有HEV Ig G阳性1 519份(40.19%),HEV Ig M阳性34份(0.90%)。115批合并血浆样品及113批血液制品成品中的HEV Ag检测结果均为阴性。结论调查的供血浆人群HEV阳性率存在地区差异,血液制品的安全性较高。

Objective To analyze the prevalence of hepatitis E virus（HEV）infection in plasma donors and blood products in 2014. Methods The plasma samples of donors from various provinces（Sichuan,Shandong and Shanxi）were determined for HEV Ag,HEV Ig M and HEV Ig G by ELISA,of which the positive ones were traced. The final product and pooled plasma were determined for HEV Ag. Results Of the 36 340 samples,26（0. 07%）were positive for HEV Ag. However,of the3 780 samples,1 519（40. 19%） were positive for HEV Ig G,and 34（0. 90%） for HEV Ig M. All the 113 batches of final products and 115 batches of pooled plasma samples were negative for HEV Ag. Conclusion The HEV positive rates in plasma of donors in various areas showed significant difference. However,the prepared blood products showed high safety.