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乙型肝炎病毒核心蛋白病毒样颗粒作为疫苗载体的研究进展 被引量：5

Progress in research on virus-like particles of hepatitis B virus core protein as a vaccine carrier
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摘要 乙型肝炎病毒核心蛋白(hepatitis B virus core protein,HBc)可自发形成二十面体的病毒样颗粒(virus-like particles,VLPs)结构,VLPs结构有利于诱发特异性的体液和细胞免疫反应。将外源性抗原表位插入至HBc的N-末端、C-末端或其内部免疫显性区,可诱导机体产生针对外源性抗原的特异性免疫应答。本文对HBc作为疫苗载体的结构基础、设计方法、佐剂效应及其应用等内容作一综述。 Hepatitis B virus core protein（HBc） can form icosahedral virus-like particles（VLPs） spontaneously. The structure of VLPs was beneficial to the induction of specific humoral and cellular immune responses. The insertion of exogenous antigen epitope into the C- and N-terminuses or internal major immune dominant region of HBc may induce the specific immune response. This paper reviews the structure, design method, adjuvant effect and application of HBc as a vaccine vector.
作者 白靓 成岩 曹瑞珍
机构地区 内蒙古民族大学生命科学学院 内蒙古民族大学医学院
出处 《中国生物制品学杂志》 CAS CSCD 2015年第12期1353-1357,1360,共6页 Chinese Journal of Biologicals
基金 内蒙古自治区自然科学基金(2011BS0401) 内蒙古民族大学博士启动基金(BS280)
关键词 乙型肝炎病毒核心蛋白 病毒样颗粒 疫苗 载体 Hepatitis B virus core protein（HBc） Virus-like particles（VLPs） Vaccine Carrier
分类号 R373.21 [医药卫生—病原生物学] R392-33 [医药卫生—免疫学]
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参考文献47

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二级参考文献146

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共引文献12

同被引文献42

引证文献5

二级引证文献10

中国生物制品学杂志
2015年 第12期

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