肥大细胞亚型与结直肠癌患者预后关系的研究

The Relationship between Mast Cell Subtype and Prognosis in Patients with Colorectal Cancer

目的：探讨肥大细胞（MC）亚型与结直肠癌患者预后的关系。方法：收集40例有完整临床、病理资料的结直肠癌患者的标本和40例正常结直肠黏膜标本,进行特殊染色和免疫组化染色。结果：MC在正常结肠黏膜组织数量4-22,平均6.7/HP。MC在肿瘤组织中数量为26-138,平均73/HP,差异有统计学意义。T型MC计数结果为0-48,平均2.2/HP。C型MC计数结果为16-83,平均51/HP。TC型MC计数结果为0-16,平均1.8/HP。C型与TC型MC与结直肠癌患者的肿瘤分化程度、临床分期和预后均无关。T型MC与结直肠癌患者的肿瘤分化程度、临床分期和预后有关,差异有统计学意义。结论：MC总数与临床预后呈负相关,T型MC与肿瘤分化程度、临床分期和预后呈负相关。

Objective：To investigate the relationship between the subtypes of mast cells and the prognosis of colorectal cancer patients.Methods：40cases of colorectal cancer with complete clinical and pathological data,and 40 normal colorectal mucosa specimens,were collected for special staining and immunohistochemical staining.Results：The number of MC in the normal colon mucosa was 4-22,and the average was 6.7/HP.The number of MC in tumor tissues from 26-138,and the average of 73/HP.T-type MC count was 0-48,the average was 2.2/HP.The C-type MC C count was16-83,the average was 51/HP.TC-type MC count was 0-16,the average was 0.8/HP.The degree of tumor differentiation,clinical staging and prognosis of C-type MC and TC-type MC were not related to the tumor differentiation and prognosis of colorectal cancer patients.The differentiation degree and clinical stage of T-type MC were related to the tumor differentiation and prognosis of the patients with colorectal cancer,and the differences were statistically significant.Conclusion：The total MC number is negatively correlated with the clinical prognosis.T-type MC is negatively related to tumor differentiation,clinical staging and prognosis but nothing with C-type MC and TC-type MC.