牛樟芝联合化疗对恶性肿瘤患者免疫功能的影响

Effect of Antrodia Camphorata combined with Chemotherapy on Immunologic Function in Patients with Malignant Tumors

目的:观察牛樟芝联合化疗对恶性肿瘤患者免疫功能及化疗毒副作用的影响。方法:将60例恶性肿瘤患者随机分为治疗组和对照组,治疗组(30例)采用牛樟芝联合化疗,对照组(30例)单纯化疗,两组同一病种化疗方案相同;观察两组化疗前后T细胞亚群及NK细胞活性的变化及生活质量和化疗毒副反应变化。结果:治疗组化疗后细胞免疫能力:CD4^+(46.92±8.41)、CD4^+/CD8^+(1.50±0.39)及CD56^+(20.55±4.43)明显高于化疗前(P<0.05);对照组CD4^+(33.71±7.14)、CD4^+/CD8^+(0.80±0.13)及CD56^+(13.44±4.42)均下降(P<0.05),化疗后治疗组CD4^+、CD4^+/CD8^+及CD56^+均明显高于对照组,而CD8^+明显降低(P<0.05);治疗组血常规在化疗前后无明显变化,对照组血常规化疗后较化疗前降低(P<0.05),两组化疗后血常规变化具有统计学差异(P<0.05);治疗组不良反应发生率较对照组低(P<0.05)。结论:牛樟芝能提高机体免疫功能,稳定血常规,促进骨髓造血功能的恢复,减少化疗毒副反应的发生,改善患者生活质量,可作为恶性肿瘤化疗的辅助用药。

ObjectiveTo evaluate the effect and side effect of Antrodia Camphorata combined with chemo-therapy on immunologic function in patients with malignant tumors.MethodsSixty cases of cancer patientswere randomly divided into treatment group（n=30） and control group（n=30）. The cases in treatment group weretreated with Antrodia Camphorata combined with chemotherapy, while control group received chemotherapy only.The activity of T cells and NK cells were examined in both groups after treatment, the toxic effects and patients＇quality of life were also observed.ResultsCom-pared with control group, the level of CD4 and CD56 and the CD4/CD8 ratio were all improved in treat-ment group after chemotherapy（33.71±7.14 vs 46.92±8.41, 13.44 ± 4.42 vs 20.55 ± 4.43, and 0.80 ± 0.13 vs1.50±0.39, P〈0.05）. In treatment group, no signifi-cant difference was found in the blood cell count after chemotherapy（P〈0.05）. In control group, however, thepatients＇ blood cell count decreased after chemotherapy（P〈0.05）. The rate of side effects was lower in the treat-ment group（P〈0.05）.ConclusionAntrodia Camphorata can improve patients＇ quality of life and immu-nity function and reduce the adverse reactions of chemotherapy when used as adjuvant chemotherapy of cancerpatients.