碱促进的不饱和烯基磺酸六氟异丙酯的成环反应

Base-Promoted Intramolecular Cyclization Reactions of Hexafluoro-isopropyl α,β-Alkenyl Sulfonates

研究了不饱和烯基磺酸六氟异丙酯的分子内成环反应,发现在催化量弱碱醋酸钠的存在下,六氟异丙氧基的α碳可进攻烯基磺酸的β位形成分子内关环产物,以中等的收率得到双三氟甲基取代五元磺酸内酯化合物.

An intramolecular cyclization reaction of hexafluoro-isopropyl α,β-alkenyl sulfonates was investigated. Catalytic amount of Na OAc was found to accelerate the addition of α-carbon of hexafluoroisopropyl moiety to β-position of unsaturated sulfonates, generating a series of trifluoromethylated five-memberring of sulfonates in moderate yields.