微波促进苊并咪唑氮杂环卡宾钯化合物催化的水相氰基化反应

Acenaphthoimidazole N-Heterocyclic Carbene Palladium Complexes Catalyzed Cyanation Reactions in Aqueous Accelerated by Microwave Irradiation

报道了一种在微波条件下,苊并咪唑氮杂环卡宾钯化合物催化的芳基溴化物的氰化反应.该反应以水作为溶剂,无毒廉价的亚铁氰化钾为氰基源,对于含各种电子效应取代基团的底物均能顺利地进行反应并且在很短的时间内取得优秀的产率,充分表明了这一方法学具有较好的实用性和绿色经济性.

In the presence of acenaphthoimidazole N-heterocyclic carbene palladium complexes, cyanation of aryl bromides by non-toxic and inexpensive potassium hexacyanoferrate（II） as cyanide source in water has been investigated under microwave conditions. Both electron-donating and electron-withdrawing groups attached to the substrates show unobvious effects on the transformation and produce the corresponding products in good to excellent yields within few minutes, which demonstrate the practicability and environmentally friendliness of the new developed protocol.