Th1细胞因子水平与鼻咽癌患者预后相关性及危险因素分析

Correlation between Th1 cytokine expression levels and prognosis of patients with nasopharyngeal carcinoma and analysis of risk factors

目的 探讨Th1细胞因子表达水平与鼻咽癌患者预后的相关性以及患者预后的危险因素。方法 选取我院2007年1月~2009年12月收治的124例鼻咽癌患者,对其预后的危险因素进行回归分析,同时对患者的Th1细胞因子（IL-2、IFN-γ及TNF-α）表达水平与预后进行相关性分析。结果 124例中,1年生存率为85.5%,3年生存率为70.2%,5年生存率为59.7%;随着生存时间的增加,患者的IL-2水平升高,TNF-α水平降低（P〈0.05）,而不同生存时间的患者,其IFN-γ比较无显著性差异（P〉0.05）;临床分期、T分期及N分期对鼻咽癌患者的生存率有显著影响（P〈0.05）,而患者的年龄、T分期、N分期以及治疗方式是影响鼻咽癌患者预后的独立危险因素。结论 鼻咽癌患者年龄越大、分期越高,其预后越差;Th1细胞因子中的IL-2及TNF-α水平可作为鼻咽癌患者预后判断的生物学指标。

Objective To discuss the correlation between Thl cytokine expression levels and prognosis of patients with nasopharyngeal carcinoma and the risk factors of prognosis, Methods Regression analysis was made in the risk factors of the prognosis among 124 patients with nasopharyngeal carcinoma who were hospitalized between January 2007 and December 2009. At the same time, the correlation between the expression levels of Thl cytokines （IL-2, IFN-γ and TNF-α and the prognosis was analyzed.Results Among the 124 cases, the one-year, three-year, and five-year survival rate was 85.5%, 70.2%, and 59.7%, respectively. Along the increase of survival time, the IL-2 levels of patients increased, and TNF-α levels decreased （P 〈 0.05）. There was no significant difference in IFN-γ, levels among the patients with different survival time （P 〉 0.05）. Clinical staging, T staging, and N staging had obvious influence on the survival rate of patients with nasopharyngeal carcinoma （P 〈 0.05）. The patients＇ age, T staging, N staging, and treatment were independent risk factors influencing the prognosis. Conclusion Along with the increase of age and staging, the prognosis is much poorer. The IL-2 and TNF-α levels can be used as biological parameters for the prognostic judgment of nasopharyngeal carcinoma.