各向异性分数在新生儿缺血缺氧性脑病早期诊断的应用

Applied Value of FA Value in Early Diagnosis of Neonatal HIE

目的探讨扩散张量成像(DTI)技术特征参数各向异性分数(FA值)在评价新生儿缺血缺氧性脑病的临床应用价值。方法选取32例检查者(轻度组6例,中度组5例,对照组15例,疑似组6例)分组进行常规磁共振和扩散张量成像检查,测量各组感兴趣区域FA值并进行统计学分析。结果常规磁共振检查:轻度组、中度组和对照组符合临床诊断,疑似组未发现异常信号;测量FA值:轻度组、中度组比对照组FA值明显降低(P<0.05),轻度组与中度组之间无明显差异(P>0.05),疑似组有两例FA值在轻度组与中度组参考值之间,有四例FA值与对照组参考值想接近。诊断疑似组有两例脑部功能损伤。结论磁共振扩散张量成像FA值在新生儿缺血缺氧性脑病的早期诊断能为临床的诊疗提供更早的影像信息。

Objective To determine the medical practice value of fractional anisotropy （FA） in neonatal brain injury. Methods 32 infants with HIE （including mild group in 6, moderate group in 5, control group in 15 and suspected group in 6） were studied. Each group was examined with conventional MR imaging and diffusion-tensor MR imaging to analyze FA value in regions of interest. Results Conventional MR imaging results： the mild group, moderate group and control group adjust to clinical diagnosis, the suspecd group haven＇t detect abnormal signal. FA values in mild group and moderate group were significantly lower than in control group （PA〈0.05）. There were no statistically differences between mild group and moderate group （P〈0.05）. FA values of two patients in suspected group ranged between mild group and moderate group, while FA values of other four patients in suspected group were not statistically significant. Two neonates in suspected group wee confirmed as neonatal brain iniury. Conclusion FA values can be obtained as an objective basis for neonatal brain injury early diagnosis.