血清淀粉样蛋白A检测在冠心病诊断中的意义

Significance of the detection of serum amyloid A in the diagnosis of coronary heart disease

目的检测冠心病(CHD)患者血清淀粉样蛋白A(SAA)水平,探讨SAA在稳定性心绞痛(SA)、不稳定性心绞痛(UA)、急性心肌梗死(AMI)患者诊断中的意义。方法选择149例CHD患者,其中42例SA,54例UA,53例AMI;健康对照组102例。所有患者均经冠状动脉造影确诊。采用西门子Advia2400全自动生化分析仪及配套试剂检测丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素、尿素氮、肌酐、尿酸及血脂,免疫荧光定量法检测血清SAA水平。结果与健康对照组相比,CHD组患者SAA水平增高,差异有统计学意义(P<0.05);AMI患者血清SAA水平明显高于SA和UA患者,差异有统计学意义(P<0.05)。结论 SAA可能参与冠心病的发生或发展,可作为CHD病情观察指标,以预防和诊断急性冠状动脉事件的发生。

Objective To detect the level of serum amyloid A（SAA）in the patients with coronary heart disease（CHD）,and to investigate the significance of SAA in the diagnosis of stable angina（SA）,unstable angina（UA）,and acute myocardial infarction（AMI）.Methods 149 cases of CHD patients（CHD group,including 42 cases of SA,54 cases of UA,and 53 cases of AMI）and 102 cases of healthy individuals（normal control group）were selected.All of the CHD patients were diagnosed by coronary arteriongraphy.The levels of ALT,AST,TBIL,BUN,Cr and UA were detected by SIEMENS Advia2400 automatic biochemical analyzer,and SAA was detected by immunofluorescence assay.Results Comparing with normal control group,the SAA level of CHD group increased significantly（P〈0.05）.And the SAA level of AMI patients was significantly higher than those of SA and UA patients,with statistical difference（P〈0.05）.Conclusion SAA might play a role in the occurrence or development of CHD,which could be an observational biomarker of CHD patient′s condition,and help to prevent and diagnose CHD.