原发性肝癌患者手术后发生感染的相关因素研究

Risk factors of postoperative infection for patients with primary hepatic carcinoma

目的探讨原发性肝癌患者手术后发生感染的相关因素。方法选取新疆医科大学附属肿瘤医院2012年2月至2015年1月收治的108例行肝切除术的原发性肝癌患者,根据术后是否发生感染分为感染组和非感染组。分析可疑危险因素与肝切除术后发生感染的关系。结果 108例患者中,20例发生术后感染,占18.52%。感染组和非感染组在糖尿病史、病灶、血管癌栓、手术时间、术中出血量、术中输血量、引流管放置时间、术前使用抗菌药物、营养不良和血清清蛋白方面比较差异有统计学意义(P<0.05),Logistic回归分析显示,合并有糖尿病、病灶多发、血管癌栓、手术时间、引流管放置时间、术前使用抗菌药物、营养不良和血清清蛋白为原发性肝癌患者手术后发生感染的独立影响因素(P<0.05)。结论合并有糖尿病、病灶多发、血管癌栓、手术时间、引流管放置时间和血清清蛋白为原发性肝癌患者手术后发生感染的独立危险因素。

Objective To investigate the risk factors of postoperative infection for patients with primary hepatic carcinoma.Methods 108 cases of patients with primary hepatic carcinoma in Tumor Hospital Affiliated to Xinjiang Medical University from February 2012 to January 2015 who were treated by hepatectomy,were selected and divided into infection group and non-infection group,according to whether with postoperative infection.The potential risk factors of postoperative infection were analyzed.Results In the total of 108 cases of patients,there were 20 patients were found with postoperative infection,accounting for 18.52%.There were significant differences of diabetes history,focus,blood vessel invasion,operation duration,intraoperative blood loss,intraoperative blood infused,time of with drainage tube,using antibiotics,malnutrition and serum albumin between infection group and non-infection group（P〈0.05）.Logistic regression showed that diabetes history,focus,blood vessel invasion,operation duration,time of with drainage tube,using antibiotics,malnutrition and serum albumin were independent risk factors of postoperative infection for patients with primary hepatic carcinoma（P〈0.05）.Conclusion Diabetes history,focus,blood vessel invasion,operation duration,time of with drainage tube,using antibiotics,malnutrition and serum albumin were independent risk factors of postoperative infection for patients with primary hepatic carcinoma.