0.1%他克莫司软膏治疗面部激素依赖性皮炎疗效观察

The observation of 0.1%tacrolimus ointment in the treatment of hormone-dependent facial dermatitis

目的观察0.1%他克莫司软膏治疗激素依赖性皮炎的疗效和安全性。方法将60例激素依赖性皮炎患者随机分为试验组和对照组,两组患者均口服复方甘草酸苷,3%硼酸溶液湿敷,试验组患者外用0.1%他克莫司软膏,对照组患者外用硅霜,均治疗4周。于用药后1周、2周、4周及停药后2周各随访1次。结果治疗后第1周、第2周、第4周,试验组有效率分别为30%、50%和80%;对照组有效率分别为3.3%、20%和40%,两组有效率比较差异有统计学意义(P<0.01、P<0.05和P<0.01);治疗结束后2周,试验组有4例患者,对照组有3例患者病情较停药前加重,但两组有效率差异仍有统计学意义(P<0.01)。结论他克莫司软膏治疗激素依赖性皮炎疗效确切,1个月疗程不足以完全修复炎症及皮肤的屏障功能,仍需增加用药周期。

Objective To explore the efficacy and safety of 0.1% tacrolimus ointment in the treatment ofhorrnone-dependent facial dermatitis. Methods Sixty patients with hormone-dependent dermatitis were randomly divided into treatment and control groups, and both of the groups were treated with compound glycyrrhizin and wet packing with 3% boric acid solution, meanwhile the treatment group was treated with 0.1% tacrolimus ointment and the control group was treated with silicon cream respectively. Follow up was given at 1, 2, 4 weeks after the beginning of the treatment and 2 weeks after the end of the treatment, conditions of the patients were recorded and comparatively analyzed. Results The clinical efficacy of the treatment group were 3.3%, 20% and 40%, the clinical efficacy of the control group were 3.3%, 20% and 40% at the 1, 2, 4 week after the beginning of the treatment respectively, the difference was significant between the two groups （P〈0.01, P〈0.05, P〈0.01）. Two weeks after the end of the treatment, there were 4 patients in the treatment group and 3 patients in the control group became worse compared to the status at the point of stopping medicine, but the significant differences still existed between the two groups in efficiency （P〈0.01）. Conclusion Tacrolimus ointment is a curative treatment of hormone-dependent dermatitis. However, a course of 4 weeks is not sufficient to fully remedy the inflammation and the skin＇s barrier function, and it still needs additional treatment courses.