线粒体钙单向转运体及其蛋白相互作用的调控

Mitochondrial calcium uniporter complex and regulation of their protein interaction

线粒体钙离子平衡对维持线粒体特性,介导多种细胞生理功能和病理过程具有重要的作用。虽然大家都知道线粒体钙离子的摄取,但直到近年来才部分揭示此过程中转运体的分子结构。本文就线粒体钙离子单向转运体（mitochondrial calcium uniporter,MCU）及其相互作用蛋白的研究进展进行综述。

Mitochondrial calcium homeostasis plays a key role in maintaining various cellular characteristics and mediating cellular physiological function and pathological processes. Although it has long been known that mitochondria takes up Ca2 ＋,the molecular identities of the channels and transporters involved in this process are revealed only recently.Here,we review the structure and function of the channel-forming subunit,mitochondrial calcium uniporter（ MCU） and its regulators,which include MICU1,MICU2,and MCUR1.