摘要
肿瘤是指在各种致瘤因子的作用下,机体局部组织细胞非典型性增生所形成的隆起物,可分为良性肿瘤和恶性肿瘤。二者的主要区别就在于恶性肿瘤在机体中呈侵袭转移性生长,而良性肿瘤一般不转移,呈局部膨胀性生长。恶性肿瘤是世界上公认重大而又非常棘手的疾病,有研究显示我国肿瘤发病率逐年升高,2012年我国癌症发病率和死亡率分别是174.0/10万和122.2/10万,
It is one of the main characters of malignant tumors that malignant tumor cells invade surrounding tissues and metastasize to distant tissues. Multiple factors are involved in this complicated dynamic process. Metastasis is the major factor influencing recurrence and prognosis. Therefore,it is important to explore the mechanism of invasion and metastasis for reducing recurrence rate and mortality of malignant tumors. Engulfment and cell mobility（ ELMO） family is one kind of conserved protein in evolutional process. It includes 3 members,ELMO1,ELMO2 and ELMO3. The members of ELMO family play an important role in cell phagocytosis and cell migration,and they also have close correlation with malignant tumor cell invasion and metastasis. In this paper,we review the progress of the relationship between ELMO family and malignant tumor invasion and metastasis.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2015年第12期2296-2300,共5页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81460462
No.31460696
No.31001128)
南昌大学研究生创新基金资助项目(No.cx2015170)
关键词
侵袭
转移
吞噬和细胞运动蛋白
恶性肿瘤
Invasion
Metastasis
Engulfment and cell mobility proteins
Malignant tumor
