青霉菌固体发酵对三七药材活性成分的影响

Chemical changes of bioactive compounds in Panax notoginseng fermented by Penicillium sp.

目的对三七药材经青霉菌发酵之后的主要活性成分变化进行研究。方法利用青霉菌对三七药材进行固体发酵,根据HPLC-Q-TOF-MS的检测结果,对三七发酵产物的主要活性成分进行分析和指认,同时考察黄曲霉素和赭曲霉素等微生物毒素的含量。结果三七药材经青霉菌发酵之后稀有皂苷含量显著提高,未见黄曲霉素和赭曲霉素产生。结论青霉菌可以对三七药材中皂苷类成分进行转化,提高稀有皂苷含量,改变药性,且未见明显的微生物毒素产生,具有一定的使用安全性。

Objective The chemical changes of bioactive compounds in Panax notoginseng fermented by Penicillium sp. were studied in this paper. Method The major components together with aflatoxins and ochratoxins of the fermented panax notoginseng were analyzed and determined by HPLC-Q-TOF-MS. Result The content of rare ginsenosides in the fermented panax notoginseng significantly increased while neither aflatoxins nor ochratoxins was detected.Conclusion The accumulation of rare ginsenosides and enhancement in efficacy of panax notoginseng could be achieved by fermenting with Penicillium sp. without any obvious biotoxins. Hence this fermentation product was either beneficial or harmless.