益母草注射液联合缩宫素对剖宫产术产后出血的影响

Leonurus japonicus injection in combined with oxytocin on postpartum hemorrhage after cesarean section

目的探讨益母草注射液联合缩宫素对剖宫产术产后出血的影响。方法选取行剖宫产分娩的150例产妇为研究对象,随机分为治疗组和对照组,各75例,2组产妇均采用腰-硬联合麻醉下行剖宫产术,对照组采用单纯缩宫素进行治疗,治疗组采用益母草注射液联合缩宫素进行治疗,观察2组产妇术中和术后0~2、2~24、24~48 h出血量,术后1~5 d子宫复旧情况,术前、术后24 h血红蛋白（Hb）及红细胞计数（RBC）,观察2组用药期间不良反应。结果治疗组术中和术后0~2、2~24、24~48 h出血量显著少于对照组（P〈0.05）;治疗组术后1~5 d子宫下降高度大于对照组（P〈0.05）;治疗组术后24 h Hb、RBC下降程度低于对照组（P〈0.05）。结论益母草注射液联合缩宫素能有效减少剖宫产术中、术后出血,降低产后出血的发生率,其起效快、止血效果好、不良反应少。

Objective To explore the effect of leonurus japonicus injection in combined with oxytocin on the postpartum hemorrhage after cesarean section. Methods A total of 150 puerpera were included in the study and randomized into the observation group and the control group with 75 cases in each group. The puerpera in the two groups were performed with cesarean section under the combined spinal-epidural anesthesia. The patients in the control group were only given oxytocin treatment,while the patients in the observation group were given leonurus japonicus injection in combined with oxytocin. The amount of bleeding during operation,0- 2 h,2- 24 h,24- 48 h after operation,the uterine involution 1- 5d after operation,Hb and RBC before operation and 24 h after operation,and the adverse reactions during the medication period in the two groups were observed. Results mount of bleeding during operation,0- 2 h,2- 24 h,24- 48 h after operation in the observation group was significantly less than that in the control group（ P〈0. 05）. The uterine fundus declining height 1- 5d after operation in the observation group was significantly greater than that in the control group（ P〈0. 05）. Hb and RBC declining degree 24 h after operation in the observation group was significantly lower than that in the control group（ P〈0. 05）. The occurrence rate of the adverse reactions in the observation group was lower than that in the control group,but the comparison was not statistically significant（ P〈0. 05）. Conclusion Leonurus japonicus injection in combined with oxytocin can effectively decrease the amount of bleeding during operation and after operation,and reduce the occurrence rate of postpartum hemorrhage with a rapid and favorable hemostatic effect and less adverse reactions; therefore,it can be served as one of the regimens for preventing postpartum hemorrhage in the clinic.