精神分裂症神经系统软体征的系统综述

Neurological soft signs in patients with schizophrenia: a systematic review

目的收集国内外2000年-2014年公开发表的关于精神分裂症神经系统软体征(neurological soft signs,NSS)的文献,综述精神分裂症NSS主要研究领域的最新研究成果,为今后研究精神分裂症NSS提供新的视角和相关理论依据。方法计算机检索Pub Med、Embase、中国知网以及万方数据库,检索精神分裂症神经系统软体征的相关文献。由2位评价员按纳入与排除标准筛选文献,评价纳入研究质量并提取原始资料后,综述精神分裂症神经系统软体征的主要研究成果。结果共检索到相关文献407篇,最终纳入25篇。结果显示精神分裂症NSS与精神分裂症阴性症状以及患者认知功能存在一定的相关性,NSS也渐渐显示出潜在的脑区皮层相关性,同时被认为是潜在的精神分裂症内表型之一。结论神经系统软体征对精神分裂症病理机制的确定具有一定的理论意义,同时对精神分裂症临床工作的完善具有指导作用;建议今后的研究对协变量做出更好的控制,拓展被试样本的年龄跨度,增加纵向研究和遗传学证据。

Objective To collect published literatures about neurological soft signs(NSS)of schizophrenia and review the latest development in mainly fields of NSS in patients with schizophrenia based on the papers published from 2000 to 2014 at home and abroad,with an attempt to provide a new prospective and related theoretical evidence for studying NSS in patients with schizophrenia. Methods Major online database including PubMed,Embase,CNKI and Wanfang data were searched with the key words "neurologi-cal soft signs" and "schizophrenia". The literatures were filtered according to the inclusion - exclusion criteria,independently by two raters who then extracted key information,on the basis of papers enrolled and evaluated through Critical Appraisal Skill Program,as foundation of the review. Results Finally 25 studies were enrolled among 407 papers searched. The analysis shows that the NSS of schizophrenia is to some extent correlated with negative symptoms and neurocognition functions in patients with the disorder,and NSS showed the significant correlation with cortex;NSS has been considered as one of the potential endophenotype of schizophrenia. Conclusion NSS has been of some significance on developing pathogenesis of schizophrenia and helping improve clinical practice of the disorder. Further studies are suggested that covariates should be controlled more strictly,and age range be extended into early -onset patients,with increasing longitudinal study and genetics evidence.