两种剂量瑞舒伐他汀治疗不稳定型心绞痛患者的临床效果

Clinical efficacy of two doses of Rosuvastatin in treatment of unstable angina pectoris

目的:研究两种不同剂量的瑞舒伐他汀在治疗不稳定型心绞痛患者时的效果及安全性。方法:将172例不稳定型心绞痛患者随机分为观察组和对照组,每组各86例。观察组患者给予瑞舒伐他汀20 mg,1次/d,睡前口服;对照组患者给予瑞舒伐他汀10 mg,1次/d,睡前口服。结果:观察组患者心绞痛症状持续时间、发作次数及总胆固醇、低密度脂蛋白胆固醇的水平低于对照组(P<0.05);观察组患者肝转氨酶、肌酸激酶(CK)、尿蛋白升高例数多于对照组,但无显著差异(P>0.05)。结论:应用高剂量瑞舒伐他汀治疗不稳定型心绞痛患者时治疗效果更可观,但应注意监测患者肝肾功能情况,若出现肝肾功能损害时应减量或停用。

Objective: To study efficacy and safety of two different doses of Rosuvastatin in treatment of unstable angina pectoris( UAP). Methods: 172 patients with UAP were randomly divided into observation group and control group,each group of 86 cases.The observation group wasorally taking Rosuvastatin tablets 20 mg every time,once a day,at bedtime,while the control group was orally taking Rosuvastatin tablets 10 mgevery time,once a day,at bedtime. Results: The duration and frequency of UAP,and TC and LDL-C levels of observation group were lower than those of control group( P < 0. 05). The patient number who LGPT,CK,PRO was increased of observation group were more than that of control group,but the difference was not significant( P > 0. 05). Conclusions: The therapeutic effect of high- dose Rosuvastatin in the patients with unstable angina pectoris is better,but the doctors should pay attention to the liver and kidney function,if liver and kidney function is damaged,it should be discontinued or reduced.