盐酸多奈哌齐用于治疗96例老年痴呆患者的临床研究

Efficacy of Donepezil Hydrochloride Treatment of 96 Cases of Senile Dementia

目的：探讨盐酸多奈哌齐治疗老年痴呆患者的临床疗效.方法：选取2012年3月~2014年11月在某院进行治疗的96例老年痴呆患者,随机分为对照组和治疗组,对照组患者给予常规治疗,治疗组在对照组的基础上采用盐酸多奈哌齐进行治疗,比较两组患者的治疗有效率、简易智能精神状态检查量表（MMSE）、日常生活能力量表（ADL）以及长谷川痴呆量表（HDS）评分.结果：治疗后,治疗组患者的MMSE、ADL以及HDS评分均明显优于对照组,与对照组相比具有统计学意义（P 〈0.05）.结论：盐酸多奈哌齐治疗老年痴呆,具有较好的临床效果,患者的认知功能和日常生活能力都得到明显的提高,值得在临床上推广使用.

Objective:To evaluate the clinical efficacy of donepezil hydrochloride treatment of Alzheimer's patients.Methods:96cases of Alzheimer's patients from March 2012 to November 2014 in our hospital for treatment,were randomly divided into a control group and the treatment group and the control group were given conventional treatment group using hydrochloric acid on the basis of the control group donepezil treatment,comparing two groups of patients treatment efficiency,easy-mental state examination(MMSE),Activities of Daily Living scale(ADL)and Hasegawa dementia Scale(HDS)score.Results:After treatment,patients treated with MMSE,ADL and HDS scores were significantly better than the control group,with statistical significance(P<0.05)compared with the control group.Conclusion:Donepezil hydrochloride treatment of senile dementia,with better clinical results,cognitive function and activities of daily living in patients have been significantly improved and should be introduced in clinical practice.