地奥心血康药理性预适应对急性心肌梗死的影响

The drug preconditioning of Diao xinxuekang capsules effect on the acute myocardial infarction

目的探讨地奥心血康胶囊药理性预适作用对急性心肌梗死预后的影响。方法对142例急性心肌梗死患者临床资料进行分析,按照梗死前无心绞痛发作但持续服用地奥心血康胶囊的患者68例作为药物预适应组,与梗死前无心绞痛病史且未服用地奥心血康胶囊的患者74例作为非预适应组,分析两组梗死范围、心肌酶峰值、LVEF、主要并发症及死亡率的差异。结果药物预适应组比非预适应组心肌梗死范围小,心肌酶峰值更低,LVEF较高,主要并发症的发生率及死亡率均小于对照组(P<0.05)。结论地奥心血康胶囊具有药理性预适应作用,可减少心梗患者的梗死范围,增强心肌细胞对缺血血氧的耐受能力,保护心功能,患者预后更佳。

Objective To study the drug preconditioning of Diao xinxuekang capsules effect on the prognosis of acute myocardial infarction. Method To analyze the clinical data of 142 cases of acute myocardial infarction（ mi） patients,Comparing angina range of infarction,myocardial enzyme peak,LVEF,main complications and mortality of68 cases of myocardial infarction who had medication history with 74 patients without myocardial infarction. Result Comparing with ischemic preconditioning group,the drug preconditioning group＇s myocardial infarction range is much small,Myocardial enzyme peak is lower,LVEF is higher,the incidence of major complications and mortality were less than the control group. Conclusion Diao xinxuekang capsules can reduce the range of myocardial infarction,enhance the blood oxygen tolerance ability of myocardial cells and protecting heart function,patients prognosis is better.