广州地区成年女性下颌角骨密度与全身及其他部位骨密度相关性研究

The correlation study of bone mineral density between mandibular angles and other regions in adult females in Guangzhou

目的探讨广州地区成年女性下颌角骨密度和全身骨、头骨、去颅全身骨、股骨、腰椎骨密度的相关性。方法随机抽取符合纳入标准的成年女性321名,年龄20~79岁运用双能X线骨密度测量仪测量研究对象的下颌角、腰椎、股骨颈、去颅全身骨及全身骨密度值,并进行Pearson相关性分析。根据世界卫生组织骨质疏松诊断标准把研究对象分为骨质正常组、骨量减少组、骨质疏松组统计不同骨质状态下下颌角骨密度的差异。结果成年女性下颌角、全身骨、头骨、去颅全身骨、腰椎、股骨颈骨密度值在35岁后均随着年龄增加而下降。Pearson相关分析显示下颌角平均骨密度值与全身骨密度值(r=0.676,P<0.001)、去颅全身骨密度值(r=0.628,P<0.001)、头骨密度值(r=0.597,P<0.001)、腰椎骨密度值(r=0.613,P<0.001)、股骨颈骨密度值(r=0.599,P<0.001)均呈正相关;与骨质分类(r=-0.720,P<0.001)、年龄(r=-0.452,P<0.001)呈负相关。骨质正常组、骨量减少组、骨质疏松组的下颌角骨密度值均数分别为1.104 g/cm^2、0.906 g/cm2和0.785 g/cm^2。经随机区组设计资料的方差分析不同骨质分组(F=110.37,P<0.001)、不同年龄段(F=2.48,P=0.032)的下颌角骨密度值的差异均有统计学意义。不同骨质分组两两比较下颌角骨密度值的差异均有统计学意义。对于全身骨质正常、骨量减少、骨质疏松的成年女性,下颌角骨密度值依次降低。结论成年女性随着年龄上升,昌密度亦逐渐降低,下颌骨骨密度值与全身各区域骨密度值相关,特别与腰椎和股骨颈骨质相关。在对成年女性患者进行口腔治疗时可根据患者年龄、已知的腰椎和股骨颈骨质状况,初步评估其颌骨骨质状况,为口腔临床疾病的诊断、治疗及预后评估提供参考。

Objective To investigate the correlations of the bone mineral density（BMD） between mandibular angle and other regions in adult females,and to evaluate the BMD of mandible depending on the other bone（lumbar spine and femur） in different states.Methods 321 females aged from 20 to 79 years old in Guangzhou were included.The dual energy X-ray absorptiometry（DXA） was used to measure the BMD of mandibular angle,lumbar spine,femur,body bone excluded the skull,the body bone separately.The data were statistically analyzed using Pearson correlation analysis.According to the World Health Organisation（WHO） criteria,the mandibular angle BMD were classified into normal,osteopennic and osteoporotic groups.Evaluate the difference of BMD in mandibular angle in different state.Results The BMD of mandibular angle and other regions（including total body,skull,body excluding skull,lumbar spin and femur）descend with age after 35 years old in adult females in Guangzhou.The BMD of mandibular angle was positive correlated with BMD of total body（r = 0.676,P〈0.001）,body excluding skull（r = 0.628,P〈0.001）,skull（r = 0.597,P〈0.001）,lumbar spin（r = 0.613,P〈0.001） and femur（r = 0.599,P〈0.001）.While,the BMD of mandibular angle was negative correlated with the classification of the bone（r =- 0.720,P〈0.001） and the age（r =- 0.452,P〈0.001）.The average BMD of mandibular angle in normal,osteopennic and osteoporotic group are 1.104,0.906 and0.785 g/cm respectively.There was significant difference among the 3 groups（F = 110.37,P〈0.001）.Conclusion The BMD of mandibular angle was declined with the age after 35 years old in adult females.It can provide preliminary information about the BMD of mandible according to the age and the BMD of the lumbar spine and the femur.